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Seafood mac and cheese takes comfort food to the next level. Shrimp, salmon, and crab get tucked into a creamy, from-scratch cheese sauce, then baked under a buttery Panko topping that turns golden and crisp. It’s rich, hearty, and a far cry from boxed mixes. Every bite delivers tender seafood, molten cheese, and that perfect crackly crust.

Seafood macaroni and cheese casserole in glass dish, spoon scooping portion.
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This seafood mac and cheese is like a cross between our creamy seafood lasagna and our Betty Crocker mac and cheese, the best of both worlds.

Here’s Why This Seafood Mac and Cheese Recipe Works

Upscales comfort food: Familiar mac and cheese gets elevated with tender shrimp, salmon, and crab for a dish that feels special but stays approachable.

Effortless seafood prep: No extra pans required. The seafood cooks gently in the sauce as the casserole bakes.

Rich flavor, light touch: A blend of Gruyere, Gouda, and Cheddar makes the sauce creamy and flavorful without being heavy.

Make-ahead friendly: Assemble it in advance and bake when ready, making it perfect for entertaining or holiday meals.

Top-down view of mac and cheese ingredients, including pasta, cheeses, and spices.

For an elegant seafood dinner, our lobster pasta is a rich and flavorful option that feels restaurant-worthy at home.

Recipe Tips

Undercook the pasta: Pull it just shy of al dente. It will finish cooking in the oven.

Coat cheese with flour: Tossing first helps it melt smoothly into the sauce without clumps.

Season carefully: The cheese adds plenty of salt, so taste before adjusting at the end.

Choose your seafood: Dungeness crab is a splurge, but canned lump crab or firm white fish like cod work well too.

Reheat gently: Add a splash of milk to each portion before warming to keep leftovers creamy.

Shred your own cheese: Pre-shredded cheese often has anti-caking agents that keep it from melting smoothly. Grating it yourself makes the sauce creamier.

Layer the seafood: For even distribution, stir some into the pasta and sauce, then scatter more on top before baking.

Rest before serving: Let the casserole sit for 5–10 minutes after baking so it sets slightly and cuts cleaner.

If you’re looking for something heartier, our turkey pasta bake is another satisfying option that’s just as comforting and family-friendly.

For another cozy baked pasta, our leek and cheese pasta bake delivers the same creamy comfort with a simpler, veggie-forward twist.

Seafood mac n cheese with parsley, lemon wedge, green grapes, and a fork.

Seafood Mac n Cheese

Seafood mac and cheese takes a classic comfort dish and gives it a rich, elegant twist. With tender shrimp, salmon, and crab tucked into a creamy cheese sauce and topped with golden Panko, it’s a casserole that feels indulgent but still approachable. Serve it for holidays, dinner parties, or any night you want mac and cheese that’s a little more special.

Seafood macaroni and cheese in a glass dish with golden breadcrumbs.

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Seafood mac n cheese with parsley, lemon wedge, green grapes, and a fork.
Prep Time: 15 minutes
Cook Time: 20 minutes
Additional Time: 15 minutes
Total Time: 50 minutes
5 from 10 votes

Seafood Mac and Cheese

Seafood mac and cheese is baked with shrimp, salmon, and crab in a creamy three-cheese sauce, topped with buttery Panko for a golden, crispy finish. This is the ultimate mac 'n cheese!

If you make this recipe, please leave a star rating and comment.

Servings: 10 servings
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Ingredients 

  • 16 ounces elbow macaroni
  • 1 tablespoon olive oil
  • 1 ½ cups Panko breadcrumbs
  • 4 tablespoons butter, melted
  • 2 cups grated Gruyere cheese
  • 2 cup grated Gouda cheese
  • 1 cup grated white Cheddar cheese
  • 3 tablespoons all-purpose flour

Cheese Sauce:

  • 8 tablespoons butter
  • 4 garlic cloves, grated or minced
  • cup all-purpose flour
  • 1 cup dry white wine
  • 6 cups whole milk
  • 1 cup heavy cream
  • teaspoon freshly grated nutmeg
  • 1 ½ teaspoon Old Bay seasonings
  • ½ teaspoon ground black pepper
  • 1 teaspoon smoked paprika
  • 2 teaspoons dried dill

The Seafood:

  • ½ pound salmon fillets, skin removed and cut into 1/2-inch cubes
  • ½ pound medium shrimp, peeled, tails removed
  • ½ pound cooked Dungeness crabmeat , free from any cartilage bits
  • 2 tablespoons fresh chopped parsley

Instructions 

  • Bring a large pot of salted water to a full boil, add the macaroni and return to a boil.  Cook for 5-minutes, stirring occasionally.  Macaroni will be cooked slightly less than ‘al dente’ but will continue to cook in the sauce.
  • Remove from the heat and drain in a colander.  Transfer the macaroni to a large mixing bowl and toss with oil, set aside.
  • Add the Panko breadcrumbs to a small mixing bowl, drizzle the melted butter over the breadcrumbs and toss to combine and set aside.
  • Place the grated cheese to a large mixing bowl and toss with the 2 tablespoons of flour, set aside.

Make the Sauce:

  • Heat the oven to 400°F and coat a 9×13-inch baking dish with oil spray.
  • In a large saucepan, melt the butter over medium heat, stir in the garlic and cook for 30 seconds.  Sprinkle with the flour.  Cook for 1 minute while stirring continually.
  • Slowly add the white wine to the flour mixture and cook for 30 seconds,while whisking.  Whisk in the milk, cream and seasonings.  Cook the sauce, whisking frequently, for 6-8 minutes until lightly thickened.  Remove the sauce from the heat and gradually add the cheese while whisking.  Continue to whisk until all the cheese has been incorporated and the sauce is thick and creamy.

Assemble and Bake:

  • Tip the sauce into the bowl of macaroni and mix until the macaroni is well coated.  
  • Add the salmon, crab and shrimp to the mixture, stirring gently to distribute evenly.  
  • Spoon the mixture into the prepared dish, smoothing the top level with a spatula.  
  • Distribute the breadcrumbs over the surface of the casserole and transfer to the oven.  Bake for 15-20 minutes until the breadcrumbs are golden brown and the edges are bubbly.
  • Transfer from the oven and serve while hot as the sauce will thicken as the casserole cools.

Notes

Cook pasta just shy of al dente: It will finish cooking in the oven. Overboiling makes it mushy.
No need to pre-cook seafood: The salmon and shrimp cook fully in the casserole.
Mix and match seafood: Use your favorites and adjust to your budget.
Season at the right time: The béchamel may taste under-salted at first. Wait until the cheese is whisked in, then adjust as needed.
Crab options: Substitute Dungeness crab with 2 (6 oz.) cans of lump crabmeat if preferred.
Cheese choices: Any good melting cheese works. Swiss, Jack, Fontina, or Mozzarella are great alternatives.
Toss cheese with flour: Coating in flour and adding it in 3 increments keeps the sauce smooth.
Serve hot: The sauce thickens as it cools, so enjoy right away for the creamiest texture.
Reheat gently: Place portions in an oven-safe dish, sprinkle 1–2 tablespoons of milk per cup of casserole, cover with foil, and warm in a 300°F oven for about 10 minutes.

Nutrition

Serving: 1 serving, Calories: 729kcal, Carbohydrates: 41g, Protein: 39g, Fat: 44g, Saturated Fat: 24g, Polyunsaturated Fat: 16g, Trans Fat: 1g, Cholesterol: 229mg, Sodium: 1194mg, Fiber: 2g, Sugar: 9g

Nutrition information is automatically calculated, so should only be used as an approximation.

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About Pat Nyswonger

Pat Nyswonger is a self-taught home cook with years of experience creating from-scratch meals for family and friends. As a wife, mother of four, and grandmother to seventeen, she understands the value of recipes that bring people together. Her kitchen has always been the heart of her home, where she enjoys developing flavorful, approachable dishes that home cooks of any level can make and enjoy.

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6 Comments

  1. Erika says:

    Hi! I can’t wait to try this recipe to serve for christmas dinner. Can I make this recipe ahead of time? Thanks so much!

    1. Dahn Boquist says:

      Yes, you can make it in advance but I recommend not baking it until you are ready to serve it. Also, the pasta will absorb the sauce when it sits for a day or two. You can either store the cooked pasta separate from the sauce or make extra cheese sauce to stir in when you heat it up.

    2. Erika says:

      @Dahn Boquist, Thank you so much Dahn!

      1. Dahn Boquist says:

        You’re welcome. Merry Christmas!

  2. angiesrecipes says:

    I have never tried a seafood mac and cheese. And I love it’s loaded with my favourite seafood. Thanks for sharing it, Pat.

    1. Pat Nyswonger says:

      Thanks, Angie…I hope you give it a try!