A lot of fat and juices will accumulate as the meatloaf cooks. Place it in a large pan so there is room for all the juices. We used a 13 x 9 baking dish. If you use a regular loaf pan, the juices will spill over the sides.
When you shape the meatloaf, pack it down firmly so it doesn't fall apart as it cooks.
When you add the ground meat, make sure you don't over-mix the mixture or the meatloaf will not be as tender.
If you like a nice brown crust on the meatloaf, do not cover it. If you like the edges soft then cover the meatloaf with aluminum foil halfway through the baking time.